Anthea P.W. Makepeace, 3rd September 2014 This file is endotrpr.html email: firstname.lastname@example.org email@example.com http:www.antheamakepeace.co.uk A Comparison of Endocrine Treatment for MtoF Transsexuals and Prostate Cancer The Endocrine treatment for Male to female transsexuals has much in common with the Androgen Deprivation Therapy (ADT) used for some forms and stages of Prostate Cancer. Cross fertilisation between the two disciplines may lead to a better understanding for example of Osteoporosis (Preston et al, 2002) We need to improve the treatment procedures especially for those being treated simultaneously for both conditions. Male to Female Transsexuals. Initial treatment is to achieve Testosterone and Oestradiol serum levels appropriate to a natal female. Subsequently Genital Reassignment Surgery (GRS) may be performed (not in all cases) which will include orchiectomy, and possibly, penotomy, and vaginoplasty. Orchiectomy maybe performed on its own but where vaginoplasty is proposed Scrotal tissue will be required as part of the reconstructive procedure. Post Orchiectomy The dose of Anti androgens will require re-evaluation in a downwards. Direction. In some cases the anti androgen effect of Oestradiol on its own is sufficient to control Androgen (Testosterone) levels in Transsexuals. Initially (1940s) oestradiol was the only available anti androgen and coupled with orchiectomy was the treatment available. Castration (sic) or Orchiectomy was still the procedure of choice until the availability of non steroidal anti-androgens References
All these references can be downloaded from the internet in their entirety.
The important references listed only in the individual bibliographies are not available for free.
Some papers are not peer reviewed and are personal views and highly provocative. Look at the original publication, if any!
Charles Huggins Nobel Lecture of 1966 elegant description of early work. It should not be overlooked.
The Wikepedia articles are easy to read and provide a useful start.
Unfortunately the important references are not available without an academic library or academic access.
Therapy Insight:parenteral estrogen treatment treatment for prostrate cancer – a new dawn for an old therapy Ockrim J., et al, Nature Clinical practice oncology Oct. 2006 Vol 3 No.10 p652 http://www.nature.com/nrclinonc/journal/v3/n10/pdf/ncponc0602.pdf Androgen deprivation in men with prostrate cancer is associated with an increased 4rate of bone loss Preston D et al Prostate Cancer and Prostatic Diseases (2002) 5, 304 -310 http://www.nature.com/pcan/journal/v5/n4/pdf/4500599a.pdf Oestradiol dosage for different conditions http://www.drugs.com/dosage/estradiol.htm NICE – Prostate Cancer Clinical Guide 175 Page24 deacovers treatmment for Hot Flushes - side effect of hormone therapy http://www.nice.org.uk/guidance/cg175/resources/guidance-prostate-cancer-diagnosis-and-treatment-pdf An Interesting website – no peer review and very few references http://www.hemingways.org/GIDinfo and specifically http://www.hemingways.org/GIDinfo/hrt_m2f.htm part of book all downloadable Menopause and Andropause :Hormone replacement Therapy through the ages -New cognition and concepts ISBN 978-3-901299-39-36 http://www.kup.at/cd-buch/8-inhalt.html Hormone Heresy – Oestrogen's Deadly Truth Sherrill Sellman (1996) Nexus Magazine http://www.whale.to/m/sellman1.html Transdermal estradiol (TDE) androgen deprivation therapy MaacK C. Pr9ostate Cancer activist. Http://www.ustoowichita.org -is a national US Prostate cancer support group http://www.ustoowichita.org/pdf/TRANSDERMAL%20ESTRADIOL.pdf Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer. Montgomery B. et al (2010) Biomedcentral is a publisher of peer reviewed open access journals http://www.biomedcentral.com/1471-2407/10/244 Estrogen action and prostate cancer Nelles J. et al (2010) http://www.ncbi.nih.gov/pmc/articles/pmc3134227/pdf/nihms3019452.pdf Prostatecancer. Net is the website of the Prostate Cancer Institute – provenance unknown -seems to be heavily loaded with advertisements) http://www.prostate.net/prostate-health/testosterone-hormones-and-prostate-health http://www.prostate.net/wp-content/uploads/pdf/questions-to-ask-your-doctor-about-hormone-therapy.pdf Useful Wikipedia articles:- http://www.en.wikipedia.org/wiki/prostate_cancer The Tumour rating score http://www.en.wikipedia.org/wiki/Gleason_score http://www.en.wikipedia.org/wiki/antiandrogen http://www.en.wikipedia.org/wiki/discovery_and_development_of_antiandrogens http://www.en.wikipedia.org/wiki/Androgen_deprivation_therapy http://www.en.wikipedia.org/wiki/estradiol PREMARIN = PREgnant Mare uRINe - first commercial Oestragen medication (1942) http://www.en.wikipedia.org/wiki/premarin First used oestrogen to treat Prostate Cancer http://www.en.wikipedia.org/wiki/Charles_Brenton_Huggins 1966 Nobel Prize for Medicine or Physiology was shared by Brenton & Rous Huggins – Endocrine Regression of Cancers -Classic paper well worth reading today http://www.nobelprize.org/nobel_prizes/medicine/laureates/1966/huggins-lecture.pdf Rous – The challenge to man of the Neoplastic Cell http://www.nobelprize.org/nobel_prizes/medicine/laureates/1966/rous-lecture.html Hormone Therapy for Prostate Cancer: What have we done with Charles Huggins' legacy? Bertrand Tombal, European Urology 61 issuee 1 Jan. 2012 26-28 http://www.europeanurology.com/article/S0302-2838%2811%2901012-8/pdf/hormone-therapy-for-prostate-cancer-what-have-we-done-with-charles-huggins-x02019-legacy `
ADT related papers firstname.lastname@example.org,uk
ADT in the treatment of advanced prostate cancer Perimutter M A, Lepor H
Rev Urol 2007, 9(Suppl 1) S3-S8 - Lots of refs all accessible
Quality of life following localised prostate Cancer treated initially with ADT or no Therapy
Potosky et al J National Cancer Institute (2002)94 (6) 430-437
Patient Information: Treatment for advanced prostate cancer (beyond the basics)
(including ADT & side effects
ADT induced fractures in men with nonmetastatic Prostate Cancer: What do we really know?
Prevalence of Osteoporosis & Osteopenia during ADT for prostate cancer
Malkowicz et al Journal of Clinical Oncology V 25 No. 165 (2007) 5116
Oestrogen replacement Therapy & Mood (popular)
Increased estradiol and improved sleep, but not hot flushes, predict mood during the menopausal transition. Hall E & Cohen LS et al
J Clin. Endocrinology & metabolism V 96, 7 (2011)
Useful Wiltshire NHS HRT guidance chart
Potential side effects of ADT in sex offenders, Giltay et al
J Am Acad of Psychiatry and the law 37, no.1 53-58 (2009)
Relationship between ADT and male meningioma, Li et al
Prostatic Cancer and Prostatic diseases 16, 387-390 (2013)
Living with hormone therapy for men with Prostate cancer pp 72